Novo Nordisk knocked off course: Eli Lilly’s pill sends shares tumbling

Novo Nordisk knocked off course: Eli Lilly’s pill sends shares tumbling

Jacob Falkencrone

Global Head of Investment Strategy

Key points:

  • Novo Nordisk shares hit hard by Eli Lilly’s new obesity pill
  • Potential U.S. drug tariffs pose additional risk to Novo
  • Investors urged to diversify and prioritize convenience-driven treatments

Imagine you're the reigning champion, dominating your market, with products flying off the shelves. Then, suddenly, an agile competitor appears with a sleek innovation that makes your star product look inconvenient and outdated. That’s precisely what happened to Novo Nordisk this week. Shares in Denmark’s pharmaceutical titan tumbled more than 7% on Tuesday, following Eli Lilly’s announcement of breakthrough trial results for their new obesity treatment pill.

Investors now face a critical question: Is this a temporary setback for Novo, or the start of a seismic shift in the market?

A pill that changed everything

Last week, Eli Lilly revealed compelling results from a late-stage trial of its obesity pill, Orforglipron. This small molecule pill demonstrated remarkable efficiency, lowering blood sugar and helping patients lose about 8% of their body weight at its highest dosage. Crucially, unlike previous treatments that required injections, this new pill can be taken daily in a straightforward manner—a convenience that resonates deeply with consumers.

"Investors love simplicity and convenience almost as much as efficacy. Eli Lilly's pill isn't merely a medical breakthrough; it’s potentially an investment game-changer."

Novo’s perfect storm

The sharp sell-off in Novo’s shares didn’t occur in isolation. Novo Nordisk’s stock, once the darling of many investors, is already down over 50% from its peak last summer. The latest Lilly announcement was the tipping point, driving shares down sharply again, by nearly 10% at market open after the Easter holiday. Analysts quickly reacted, revising their forecasts downward—some slashing Novo’s expected future revenues by as much as 20%.

Novo was also hit by a downgrade from Canadian investment house BMO Capital, alongside reduced price targets by other analysts, signalling that Wall Street sees storm clouds ahead.

From injections to pills: why ease matters

Novo Nordisk built much of its success on injectable drugs like Wegovy and Ozempic, treatments that have captured global attention and driven stellar growth. But investors are quickly discovering that convenience could trump efficacy alone.

Think of it like the move from flip phones to smartphones: Once a simpler, sleeker option arrives, going back feels unthinkable. Novo does have its own pill, Rybelsus, but it hasn’t achieved nearly the same market traction as its injectable versions. The pressure is now firmly on Novo to innovate further or risk losing ground permanently.

Investor alert: diversification isn’t optional

In Denmark, Novo Nordisk holds a special place in investor portfolios, often forming a significant portion of their investments. But the sharp drop underlines the danger of placing too many chips on one stock—no matter how promising it once seemed.

"The sell-off is a clear reminder that diversification isn’t just a theory—it’s essential risk management. Investors need to resist the temptation of doubling down on a falling star and instead consider spreading their bets more strategically."

This isn’t to say Novo Nordisk is down and out—far from it. The company retains deep expertise and a strong pipeline. Yet, the swift shift in market sentiment underscores the speed with which conditions can change, making diversification vital.

A balanced approach

The recent events teach retail investors three crucial lessons:

  1. Diversify your portfolio: Novo’s sudden plunge highlights how quickly one stock’s fortune can shift. Spread your risks.
  2. Convenience matters: Future success in pharmaceuticals, as in technology, might hinge as much on convenience and user-friendliness as on pure effectiveness.
  3. Stay informed, stay agile: Rapid market changes demand investors remain alert, adapting quickly rather than stubbornly holding onto past winners.

In investment, much like in medicine, prevention trumps cure every time. Taking preventative measures—like diversification—can mean the difference between financial health and a portfolio in trouble.

Staying steady amid the storm

While Novo Nordisk navigates this challenging period, smart investors will be looking carefully at their portfolios. Eli Lilly’s pill might not mean the end for Novo—but it does signal that the rules of engagement have shifted.

As the market digests this significant news, remember that a balanced approach can protect you against volatility. Markets constantly evolve, and so should your investment strategy.

The market reaction reminds us clearly: investing is not about avoiding storms entirely—it’s about learning how to weather them safely.

Quarterly Outlook

01 /

  • Upending the global order at blinding speed

    Quarterly Outlook

    Upending the global order at blinding speed

    John J. Hardy

    Global Head of Macro Strategy

    We are witnessing a once-in-a-lifetime shredding of the global order. As the new order takes shape, ...
  • Equity outlook: The high cost of global fragmentation for US portfolios

    Quarterly Outlook

    Equity outlook: The high cost of global fragmentation for US portfolios

    Charu Chanana

    Chief Investment Strategist

  • Asset allocation outlook: From Magnificent 7 to Magnificent 2,645—diversification matters, now more than ever

    Quarterly Outlook

    Asset allocation outlook: From Magnificent 7 to Magnificent 2,645—diversification matters, now more than ever

    Jacob Falkencrone

    Global Head of Investment Strategy

  • Commodity Outlook: Commodities rally despite global uncertainty

    Quarterly Outlook

    Commodity Outlook: Commodities rally despite global uncertainty

    Ole Hansen

    Head of Commodity Strategy

  • Macro outlook: Trump 2.0: Can the US have its cake and eat it, too?

    Quarterly Outlook

    Macro outlook: Trump 2.0: Can the US have its cake and eat it, too?

    John J. Hardy

    Global Head of Macro Strategy

  • Equity Outlook: The ride just got rougher

    Quarterly Outlook

    Equity Outlook: The ride just got rougher

    Charu Chanana

    Chief Investment Strategist

  • China Outlook: The choice between retaliation or de-escalation

    Quarterly Outlook

    China Outlook: The choice between retaliation or de-escalation

    Charu Chanana

    Chief Investment Strategist

  • Commodity Outlook: A bumpy road ahead calls for diversification

    Quarterly Outlook

    Commodity Outlook: A bumpy road ahead calls for diversification

    Ole Hansen

    Head of Commodity Strategy

  • FX outlook: Tariffs drive USD strength, until...?

    Quarterly Outlook

    FX outlook: Tariffs drive USD strength, until...?

    John J. Hardy

    Global Head of Macro Strategy

  • Fixed Income Outlook: Bonds Hit Reset. A New Equilibrium Emerges

    Quarterly Outlook

    Fixed Income Outlook: Bonds Hit Reset. A New Equilibrium Emerges

    Althea Spinozzi

    Head of Fixed Income Strategy

The information on or via the website is provided to you by Saxo Bank (Switzerland) Ltd. (“Saxo Bank”) for educational and information purposes only. The information should not be construed as an offer or recommendation to enter into any transaction or any particular service, nor should the contents be construed as advice of any other kind, for example of a tax or legal nature.

All trading carries risk. Loses can exceed deposits on margin products. You should consider whether you understand how our products work and whether you can afford to take the high risk of losing your money.

Saxo Bank does not guarantee the accuracy, completeness, or usefulness of any information provided and shall not be responsible for any errors or omissions or for any losses or damages resulting from the use of such information.

The content of this website represents marketing material and is not the result of financial analysis or research. It has therefore has not been prepared in accordance with directives designed to promote the independence of financial/investment research and is not subject to any prohibition on dealing ahead of the dissemination of financial/investment research.

Saxo Bank (Schweiz) AG
The Circle 38
CH-8058
Zürich-Flughafen
Switzerland

Contact Saxo

Select region

Switzerland
Switzerland

All trading carries risk. Losses can exceed deposits on margin products. You should consider whether you understand how our products work and whether you can afford to take the high risk of losing your money. To help you understand the risks involved we have put together a general Risk Warning series of Key Information Documents (KIDs) highlighting the risks and rewards related to each product. The KIDs can be accessed within the trading platform. Please note that the full prospectus can be obtained free of charge from Saxo Bank (Switzerland) Ltd. or the issuer.

This website can be accessed worldwide however the information on the website is related to Saxo Bank (Switzerland) Ltd. All clients will directly engage with Saxo Bank (Switzerland) Ltd. and all client agreements will be entered into with Saxo Bank (Switzerland) Ltd. and thus governed by Swiss Law. 

The content of this website represents marketing material and has not been notified or submitted to any supervisory authority.

If you contact Saxo Bank (Switzerland) Ltd. or visit this website, you acknowledge and agree that any data that you transmit to Saxo Bank (Switzerland) Ltd., either through this website, by telephone or by any other means of communication (e.g. e-mail), may be collected or recorded and transferred to other Saxo Bank Group companies or third parties in Switzerland or abroad and may be stored or otherwise processed by them or Saxo Bank (Switzerland) Ltd. You release Saxo Bank (Switzerland) Ltd. from its obligations under Swiss banking and securities dealer secrecies and, to the extent permitted by law, data protection laws as well as other laws and obligations to protect privacy. Saxo Bank (Switzerland) Ltd. has implemented appropriate technical and organizational measures to protect data from unauthorized processing and disclosure and applies appropriate safeguards to guarantee adequate protection of such data.

Apple, iPad and iPhone are trademarks of Apple Inc., registered in the U.S. and other countries. App Store is a service mark of Apple Inc.